-an inherited deficiency of a blood-clotting factor that results in excessive bleeding
When you bleed, the body launches a series of reactions that help the blood clot. This is called the coagulation cascade. The process involves special proteins called coagulation factors. When one or more of these clotting factors are missing, there is usually a higher chance of bleeding.Types:
    • Hemophilia A
      • Most common, caused by a lack of enough clotting factor VIII
    • Hemophilia B
      • Caused by a lack of clotting factor IX
    • Hemophilia C
      • Least common type, lack of clotting factor XI and symptoms are often mild with this type of hemophilia.
  • Cause
    • lack of enough factor VIII or IX, (in most cases) hemophilia is inherited; and affects most males.
    • Inherited
      • Only from the X-Chromosome
    • Sometimes aquired by a mutation
    • Signs and Symptoms
      • Many large or deep bruises
      • Joint pain and swelling caused by internal bleeding
      • Unexplained and excessive bleeding or bruising
      • Blood in your urine or stool
      • Prolonged bleeding from cuts or injuries or after surgery or tooth extraction
      • Nosebleeds without a known cause
      • Tightness in your joints
      • In infants, unexplained irritability
      • Unusual bleeding after immunizations
      • Sudden pain, swelling, and warmth of large joints, such as knees, elbows, hips and shoulders, and of the muscles of your arms and legs
      • Bleeding from an injury, especially if you have a severe form of hemophilia
      • Painful, lasting headache
      • Repeated vomiting
      • Extreme fatigue
      • Neck pain
      • Double vision
  • Treatments
    • Standard treatment involves replacing the missing clottting factor through a vein called intravenous infusions.
      • Diagnosing a bleeding disoreder is important so that a doctor can take extra care of a patent incase he/she needs surgery, and can test or warn other family members who possibly could be affected.
        • Many people are able to lead normal lives. However, some patients have major bleeding events and a small percentage of people with hemophilia die from severe bleeding.
    • Patients may recieve blood donations from others without hemophilia to give the patient some clotting factors.
    • Also there is genetic engineering to help reduce the chance of a child having hemophilia.
    • People with hemophilia should not use Asprin because Asprin prevents the blood from clotting and this is dangerous to people with hemophilia because their blood already doesn't clott well.

  • Interesting facts
    • A cure is currently being developed
      • new genetic material that instructs the cells to produce either factor VIII or factor IX, which the cells are then reinserted back into the person with hemophilia.
        • There have been many successes with both animal and humans.
    • Bleeding is most common in joints from the contant movement.

Works Cited

“Hemophilia – PubMed Health.” National Center for Biotechnology Information. N.p., n.d. Web. 24 Feb. 2012. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001564/.

"What Is Hemophilia? - NHLBI, NIH." NIH Heart, Lung and Blood Institute. N.p., n.d. Web. 24 Feb. 2012. http://www.nhlbi.nih.gov/health/health-topics/topics/hemophilia/.

Izenberg, Neil. Human diseases and conditions. New York: Scribner/Thomson/Gale, 20002003. Print.
"Hemophilia - MayoClinic.com." Mayo Clinic. N.p., n.d. Web. 28 Feb. 2012. <http://www.mayoclinic.com/health/hemophilia/DS00218>.

Cure, ordering your factor through "Homecare for the, " you, too, can be a part of the answer because a portion of every order goes towards finding a cure for hemophilia. So far we have spent over $ 200, the more we can donate, and supplies. "Cure for Hemophilia." Welcome to the Hemophilia Information site. N.p., n.d. Web. 28 Feb. 2012. <http://www.hemophilia-information.com/Cure-for-hemophilia.html>.

"Genome Editing Found as the Precise Cure for Hemophilia in Mice | Health Doctrine." Health Doctrine. N.p., n.d. Web. 2 Mar. 2012. <http://healthdoctrine.com/genome-editing-precise-cure-for-hemophilia-in-mice/>.


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