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George Huntington, the man who first accurately described the disease in his paper, "On Chorea"

Huntington's Disease: is a disorder that is passed down by family members. The disease degenerates or wastes away nerve cells in certain parts of the brain. Support Site

Causes: This disease is caused by a genetic defect on chromosome 4.

How it comes into effect: The defect on chromosome four causes DNA called CAG to repeat. Now normally CAG is repeated and it is repeated 10 to 28 times. Those with Huntington's Disease have CAG repeated 36 to 120 times.
CAG_Repeat.jpg
The CAG repeat elongates the protein,Huntingtin, which cause the disease.


Passed Down: When the Gene is passed down through families the number of CAG repeats get larger. The more repeats there are, it is more likely for the affected
person to have the disease at a younger age.
Two forms of Huntington's Disease: The most common form of Huntington's Disease is adult-onset Huntington's disease. Adults usually develop symptoms in their mid 30's-40's. The other form is early-onset Huntington's disease, and it accounts for a small
number of cases and begins in childhood or adolescence.
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Dark: Infected Circle:Femle Square:Male

Chances of having the Disease: There is a 50% chance of attaining Huntington's
Disease through your parents if they have it. Luckily if you do not attain the disease you can not pass it onto your children. But the Huntington's Disease gene is dominate. It is not Homozygous dominate.
Symptoms: Behavior changes may occur before movement problems: (Can include)
Loss of brain tissues deep in the brain.
Behavioral disturbances- A condition exhibiting one or more of the following characteristics of a long period of time. And the disturbance can affect a child's educational perfomance.
  • (A) The sufferer does not have the ability to learn, and take in information. The reason why cannont be explained by intellectual reasoning, the inability to comprehend through senses, or health factors that limit the sufferer.
  • (B) They cannot build relationships amongts peers and teachers
  • (C) They have inappropiate behavioral and feeling responses to completely normal circumstances.
  • (D) A general pervasive mood of unhappiness or depression.
  • (E) A tendencey to develop physical symptom or fears associated with personal or school problems.
Hallucinations- When the sufferer starts to see images that aren't really there.
Irritability- Annoyance, impatience or anger.
Paranoia- A mental disorder that invovles delusions.
Pyschosis- Fundamental derangement of the mind.
Moodiness- Subject to mood swings
Abnormal and Unusual movements include:
  • Facial movements including grimaces
  • Head turning to shift eye position
  • Quick sudden, and sometimes wild jerking moviemnts of the arms legs, face and other body parts
  • Slow uncontrolled movements
  • Unsteady gate
  • Hesitant Speech, poor enounciation
  • Speech impediment
  • "Prancing", wide walk
Dementia (A severve impairment to the the brain that concludes losing intellectual capacity, personaility, due to the loss of nerves or brain injury) that slowly gets worse.
  • Disorientation of confusion
  • Loss of Judgement
  • Loss of memory
  • Personaility changes
  • Speech Changes
Symptoms more commonly found in children-
  • Rigidity
  • Slow movements
  • Tremors
Ways to find the disease:
  • CT scan
  • PET (isotope) scan
  • MRI scan
Treatment: There is no known cure.
Medications
Dopamine- Blockers that reduce abnormal behaviors and movements
Co-Enzyme Q10: Slows disease down.
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Huntington's Disease is a dominant gene

The History of the Disease: Huntington's was first recognizes in 1872 when Dr. George Huntington addressed it in his published article on what he called "Chorea". George Huntington was only 22 years old when he published this article. In 1983 the discovery of the disease being linked to the fourth chromosome was released.
Facts: Cannot be cured or stopped
  • Death is not usually caused by the disease
  • A.K.A Chorea (Greek for dance)
  • The disease is uncommon
  • 1 in 10,000-25,000 births will get the disease

-Support-

Bunch, Bryan H.. Diseases: volume 4, gangrene to infantile paralysis. Danbury, CT: Grolier Educational, 1997. Print.
"Dr. George Huntington and the Disease Bearing His Name." Lakewood Public Library (Lakewood, Ohio). N.p., n.d. Web. 2 Mar. 2012. <http://www.lkwdpl.org/hdsa/conomy.htm>.
"Huntington's Disease ." Unknown. N.p., n.d. Web. 24 Feb. 2012. <www.kume.edu/hospital/huntingtons/genetic.html >.
"Huntington's disease - PubMed Health." National Center for Biotechnology Information. N.p., n.d. Web. 2 Mar. 2012. <http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001775/>.
"Information ." Unknown . N.p., n.d. Web. 24 Feb. 2012. <www.ahdansw.asn.au/information/faq-history.html >.
"Unknown." Unknown. N.p., n.d. Web. 24 Feb. 2012. [[http://www.ninds.nih.gove/disordres/huntington/huntington.htm |www.ninds.nih.gove/disordres/huntington/huntington.htm ]].